Furin Cleavage Bioinformatics

• Analyze furin cleavage sites in protein sequences from different organisms: mammal, bactria and virus, and investigate biology of furin substrates
• Develop database and computational tools for furin cleavage
• Study molecular mechanism of furin cleavage associated human diseases, design drugs targeting proteolytic cleavage of furin and other proprotein convertases

 

A webserver of computational Furin cleavage site prediction tool will be available on this page. Computational Furin cleavage site prediction tool is also now available for download. Pls. see supplementary material of publication link or this download link

Reference:

Sun Tian, Wang Huajun, Jianhua Wu. (2012) Computational prediction of furin cleavage sites by a hybrid method and understanding mechanism underlying diseases. Scientific Reports. 2, 261.

Sun Tian and Wu Jianhua. (2010) Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. International Journal of Biological Sciences., 2010, 6, 89-95.