*** Research interests ***
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Sun Tian
Other links I am a bioinfomratics scientist. My work focus on:
1. Bioinformatics for target discovery and target validation of immuno oncology/antibody drugs. Product development of cancer companion diagnostics and personalized medicine.
2. Computational biology of Furin cleavage and associated human diseases (from 2008-2011 collaborated with South China University of Technology). Publications are marked with
symbol.
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Sjors G. J. G. In ’t Veld 1, Kim N. Duong, Mireille Snel, Anke Witteveen, Inès J. Beumer, Leonie J.M.J. Delahaye, Diederik Wehkamp, René Bernards, Annuska M. Glas, Sun Tian.
(2017)
A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers.
High-Throughput 6, no. 4: 16.
Loredana Vecchione, Valentina Gambino, Jonne Raaijmakers, Andreas Schlicker, Arianna Fumagalli, Mariangela Russo, Alberto Villanueva, Evelyne Beerling, Alice Bartolini, David G. Mollevi, Nizar El-Murr, Marielle Chiron, Loreley Calvet, Céline Nicolazzi, Cécile Combeau, Christophe Henry, Iris M. Simon, Sun Tian, Sjors in ‘t Veld, Giovanni D’ario, Sara Mainardi, Roderick L. Beijersbergen, Cor Lieftink, Sabine Linn, Cornelia Rumpf-Kienzl, Mauro Delorenzi, Lodewyk Wessels, Ramon Salazar, Federica Di Nicolantonio, Alberto Bardelli, Jacco van Rheenen, René H. Medema, Sabine Tejpar, René Bernards. (2016) A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility. Cell 165, 317–330.
Iméne Kara, Marjorie Poggi, Bernadette Bonardo, Roland Govers, Jean-François Landrier, Sun Tian, Ingo Leibiger, Robert Day, John W. M. Creemers, Franck Peiretti. (2014) The Paired Basic Amino Acid-Cleaving Enzyme 4 (PACE4) is Involved in the Maturation of Insulin Receptor Isoform B: An opportunity to reduce the specific insulin receptor-dependent effects of IGF2. Journal of Biological Chemistry.
Paul Roepman, Andreas Schlicker, Josep Tabernero, Ian Majewski, Sun Tian, Victor Moreno, Mireille H Snel, Christine M Chresta, Robert Rosenberg, Ulrich Nitsche, Teresa Macarulla, Gabriel Capella, Ramon Salazar, George Orphanides, Lodewyk F. A. Wessels, Rene Bernards, Iris Simon. (2013) Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition. International Journal of Cancer., doi: 10.1002/ijc.28387
Sun Tian, Iris Simon, Victor Moreno, Paul Roepman, Josep Tabernero, Mireille Snel, Laura van't Veer, Ramon Salazar, René Bernards, Gabriel Capella. (2013) A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction. Gut., doi:10.1136
Veerle De Vriendt, Wendy De Roock, Antonio Fabio Di Narzo, Sun Tian, Bart Biesmans, Bart Jacobs, Eva Budinska, Xavier Sagaert, Simona Rossi, Giovanni D’Ario, Mauro Delorenzi, Iris Simon, Loredana Vecchione, and Sabine Tejpar. (2013) DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype. Biomarkers., doi:10.3109/1354750X.2013.819038
Sun Tian, Paul Roepman, Vlad Popovici, Magali Michaut, Ian Majewski, Ramon Salazar, Cristina Santos, Robert Rosenberg, Ulrich Nitsche, Wilma E Mesker, Sjoerd Bruin, Sabine Tejpar, Mauro Delorenzi, Rene Bernards, Iris Simon. (2012) A robust genomic signature for detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency. Journal of Pathology., doi: 10.1002/path.4092
Sun Tian, Wang Huajun, Jianhua Wu. (2012) Computational prediction of furin cleavage sites by a hybrid method and understanding mechanism underlying diseases. Scientific Reports. 2, 261.
- Supplementary material:
1. PiTou Furin cleavage site computational prediction tool download guide (excutable file on Windows platform): download
Sun Tian, Qingsheng Huang, Ying Fang, Jianhua Wu. (2011) FurinDB: a database of 20-residue furin cleavage site motifs, substrates and their associated drugs. International Journal of Molecular Sciences., 12, 1060-1065.
Oscar Krijgsman, Paul Roepman, Wilbert Zwart, Jason S. Carroll, Sun Tian, Femke A. de Snoo, Richard A. Bender, René Bernards and Annuska M. Glas. (2011) A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response. Breast Cancer Research and Treatment.
Sun Tian, Paul Roepman, Laura J van’t Veer, René Bernards, Femke de Snoo, and Annuska M Glas. (2010) Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer. Biomarker Insights., 5, 129-138.
Ernst-Jan Geutjes, Sun Tian, Paul Roepman and René Bernards.(2011) Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs. Breast Cancer Research and Treatment.
Sun Tian and Wu Jianhua. (2010) Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. International Journal of Biological Sciences., 2010, 6, 89-95.
- Supplementary material:
Multiple sequence alignment of the binding pockets of mammalian proprotein convertases : download
Sun Tian. (2009) A 20 Residues Motif Delineates the Furin Cleavage Site and its Physical Properties May Influence Viral Fusion. Biochemistry Insights., 2, 9-20.
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Supplementary material:
List of all correlation coefficient R > 0.65 in region P14--P6' on the Furin cleavage site motif: download
*** Patents ***
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US20130302321 / EP2622099 / WO2012044167 Methods and means for typing a sample comprising cancer cells based on oncogenic signal transduction pathways. Publication date: 2013.
US20130296191 / EP2655661 / WO2012087144 Methods and means for molecular classification of colorectal cancers. Publication date: 2011.
EP17150559/US/WO nr. pending Biomarkers for selecting patient groups, and uses thereof. Filing date: 2017.